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Q.1
Which cell type in the kidney expresses uromodulin (Tamm-Horsfall protein)?
A. Collecting Duct
B. Thick ascending limb
C. Podocytes
D. Proximal Tubule
Q.2
Which transcription factor positively regulates uromodulin expression?
A. Hepatic nuclear factor 1β (HNF1β)
B. c-Jun
C. E twenty-six (ETS)-like transcription factor 1 (ELK1)
D. Signal Transducers and Activators of Transcription 1 (STAT1)
Q.3
The presence of uromodulin is necessary for urinary cast formation.
A. True
B. False
Q.4
UMOD variants have been associated with which of the following?
A. Decreased risk of chronic kidney disease
B. Familial juvenile hyperuricemic nephropathy
C. Both
Q.5
Uromodulin has been found to have an immunosuppressive effect on which cell type in vitro?
A. Monocytes
B. Neutrophils
C. Dendritic cells
D. T cell
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