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Will someone try reproductive human CRISPR in next 10 years?

Posted 2 weeks.

1 Comment

  • Chneiweiss - 2 weeks ago

    This will depend on how we answer two main questions:
    1- Many technical hurdles prevent CRISPRing human embryos including monitoring off-targets, monitoring on-targets, monitoring the HDR repair, monitoring the stability of the repair. Both safety and efficacy must be close to 100% to move to herotable DNA change.
    2- Why CRISPRing a human embryo? The cases for couple both affected and homozygous for a genetic disease are extremely rare and should hardly justify such a difficult research. Much more frequent are the cases of unsucessfull PGD with several viable affected embryos. These might be the targets if other technical improvements are not coming to change the landscape. see Steffann et al. Cell Stem Cell 2018 Apr 5;22(4):481-482. doi: 10.1016/j.stem.2018.01.004.

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