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Q.1
A patient is found to have a decreased hemoglobin and an increased mean cell volume (MCV). Which of the following is the most likely diagnosis?
Iron deficiency
Thalassemia
Anemia of chronic disease
Vitamin B12 or folate deficiency
Q.2
All of the following statements are true regarding vitamin B12/folate deficiency anemia EXCEPT:
It is characteristically a macrocytic anemia
Vitamin B12 stores in the body generally last for 3 months without replenishment
The hallmarks of the blood smear include macrocytes (large red blood cells) and hypersegmented neutrophils
Folate deficiency anemia is frequently seen in chronically malnourished individuals such as alcoholics
Q.3
A patient presents with a decreased hemoglobin and a decreased mean cell volume (MCV). The neutrophil and platelet count are normal. Which of the following is the most likely diagnosis?
Vitamin B12 or folate deficiency
Aplastic anemia
Sickle cell anemia
Either iron deficiency or thalessemia
Q.4
Which of the following sets of lab values best fits sickle cell anemia?
Hgb decreased, MCV decreased, reticulocyte count decreased
Hgb normal, MCV normal, reticulocyte count normal
Hgb decreased, MCV increased, reticulocyte count decreased
Hgb decreased, MCV normal, reticulocyte count increased
Hgb normal, MCV decreased, reticulocyte count decreased
Q.5
Which of the following sets of lab values best fits iron-deficiency anemia?
Hgb decreased, MCV decreased, reticulocyte count decreased
Hgb normal, MCV normal, reticulocyte count normal
Hgb decreased, MCV increased, reticulocyte count decreased
Hgb decreased, MCV decreased, reticulocyte count increased
Hgb normal, MCV decreased, reticulocyte count decreased
Q.6
Which of the following is true regarding leukemia?
Acute lymphoblastic leukemia (ALL) is more common than acute myeloid leukemia (AML) in children
Chronic leukemias are composed mostly of blast cells
CML is most common in children
Acute leukemia is generally not accompanied by bone marrow failure (i.e. thrombocytopenia, anemia and neutropenia)
Q.7
Which of the following is/are true about acute myeloid leukemia (AML)?
A patient with l5% myeloblasts in the blood or bone marrow can be diagnosed as having AML
Myeloblasts usually express myeloperoxidase (MPO) enzyme
Both
Neither
Q.8
Infiltrates of the gingiva are particularly characteristic of which of the following leukemias?
Chronic myeloid leukemia (CML)
Acute monoblastic leukemia (AML-M5A)
B-cell acute lymphoblastic leukemia
Chronic lymphocytic leukemia
Q.9
The Philadelphia chromosome involves a translocation between chromosomes _____ and is always present in _______.
8 and 21; acute myeloid leukemia (AML)
8 and 21; chronic myeloid leukemia (CML)
9 and 22; AML
9 and 22; CML
Q.10
Which of the following is true regarding Hodgkin disease?
It frequently arises in the intestines
It responds poorly to current chemotherapeutic regimens
It tends to spread in a contiguous fashion
It typically presents only in elderly patients
Q.11
All of the following statements are true regarding lymphoma EXCEPT:
Hodgkin's lymphoma generally has a good prognosis
The malignant cell of Hodgkin's lymphoma is the Reed-Sternberg cell
Low grade lymphomas frequently can be cured by chemotherapy
Follicular lymphomas are all B-cell lymphomas
Q.12
Which of the following is a LOW grade lymphoma?
Follicular lymphoma
Diffuse, large B-cell lymphoma
Burkitt lymphoma
Anaplastic large-cell lymphoma
Q.13
All of the following statements are true regarding myeloma EXCEPT:
Characterized by a clonal proliferation of plasma cells
Often produces lytic lesions especially of skull
Bone marrow shows histiocytes with Birbeck granules
Associated with monoclonal gammopathy
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